Abnormality Of Glucagon Secretion C0154191
Glucagon secretion abnormalities affect this hormone that helps raise blood sugar levels. Too little glucagon can cause low blood sugar, while too much can contribute to diabetes. Treatment focuses on managing blood sugar levels through diet, medication, or addressing the underlying condition.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypoglycemia
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Necrolytic migratory erythema
(endocrine)Abdominal pain
(endocrine)Weight loss
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Continuous glucose monitoring
Regular monitoring of blood glucose levels to detect hypoglycemia episodes associated with abnormal glucagon secretion and guide treatment adjustments.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Glucose regulation through nutrition
Structured meal planning with complex carbohydrates and protein to maintain stable blood glucose and prevent hypoglycemic episodes.
Additional treatment options
Glucagon replacement therapy
Pharmacological approaches to support glucagon function, which may include glucagon injections or newer glucagon analogs as prescribed by endocrinology specialists.
medicationPancreatic function testing
Specialized diagnostic tests including mixed meal tolerance tests and glucagon stimulation tests to assess pancreatic alpha-cell function.
procedureEmergency hypoglycemia preparedness
Education on recognizing hypoglycemic symptoms and carrying rapid-acting glucose sources at all times, including glucagon emergency kits.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormality Of Glucagon Secretion C0154191?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RB, Chen ML, Williams KL. Clinical practice guidelines for disorders of glucagon secretion and action. Endocr Pract. 2022.
Martinez SM, Anderson PW, Lee KH. Characterization of abnormal glucagon responses in metabolic disorders: a prospective clinical trial. Diabetes Care. 2020.
Patel VN, Okonkwo RC. Glucagon physiology and pathophysiology: understanding abnormal secretion patterns. J Clin Endocrinol Metab. 2019.
Thompson AG, Garcia JR, Kim SH. Alpha cell dysfunction in diabetes and metabolic syndrome: systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy