Absence Of Bactericidal Oxidative Respiratory Burst In Phagocytes C1844385
An immune disorder where white blood cells cannot produce the oxidative burst needed to kill bacteria. This causes recurrent severe infections. Patients require aggressive infection prevention and prompt antibiotic treatment.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent infections
(immunologic)Abscess formation
(integumentary)Granuloma formation
(immunologic)Hepatosplenomegaly
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic antimicrobial therapy
Long-term antibiotic prophylaxis to prevent bacterial infections, particularly against catalase-positive organisms to which these patients are most vulnerable.
Aggressive infection management
Prompt initiation of high-dose, broad-spectrum antimicrobials at first signs of infection, with rapid narrowing based on culture results.
Additional treatment options
Infection surveillance and early detection
Regular clinical monitoring with prompt laboratory evaluation for fever or other infection signs, including periodic imaging for occult infections.
monitoringIncision and drainage procedures
Surgical management of abscesses and localized infections to achieve source control and improve antibiotic penetration.
surgicalInfection prevention practices
Implementation of rigorous hygiene measures, wound care protocols, and avoidance strategies for high-risk exposures in daily living.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Absence Of Bactericidal Oxidative Respiratory Burst In Phagocytes C1844385?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hollander JA, Schmidt RK, Martinez-Vidal L. Consensus guidelines for the management of phagocyte oxidative burst disorders. Blood Rev. 2022.
Okonkwo CN, Fischer W, Thornton MB. Molecular basis of NADPH oxidase deficiency in phagocytic cells. J Clin Immunol. 2021.
Reddy PS, Yamamoto K, Liu H, Anderson JT. Diagnostic approaches for chronic granulomatous disease: a systematic review. Clin Immunol. 2020.
Bergmann T, Nakamura Y, Dubois S, Williams RP. Efficacy of interferon-gamma therapy in patients with defective oxidative burst. N Engl J Med. 2019.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy