Absence Of Intermediate Von Willebrand Factor Multimers C5826356
A bleeding disorder involving defective von Willebrand factor, a protein needed for clotting. Patients may have prolonged bleeding. Treatment includes clotting factor replacement.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Post-procedural hemorrhage
Epistaxis
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Gingival bleeding
(hematologic)Easy bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Desmopressin Acetate
Synthetic hormone that stimulates release of von Willebrand factor and factor VIII to temporarily improve clotting capacity during bleeding episodes or procedures.
Von Willebrand Factor Concentrate Infusion
Replacement therapy providing functional von Willebrand factor for significant bleeding or surgical prophylaxis when Desmopressin is ineffective or contraindicated.
Additional treatment options
Antifibrinolytic Agents
Tranexamic acid or aminocaproic acid to stabilize clots by preventing their breakdown, particularly useful for mucosal bleeding.
medicationCoagulation Factor Monitoring
Regular blood tests including VWF antigen, activity levels, and multimer analysis to guide treatment decisions and assess disease severity.
monitoringBleeding Precaution Measures
Avoidance of NSAIDs, antiplatelet drugs, and contact sports; use of soft-bristled toothbrushes and medical alert identification.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Absence Of Intermediate Von Willebrand Factor Multimers C5826356?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Leebeek FWG, Eikenboom JCJ, Van der Sluijs H, et al. ISTH-SSC International Collaborative Study on the Diagnosis and Management of Von Willebrand Disease Type 2. J Thromb Haemost. 2021.
Lenting PJ, Denis CV, Christophe OD. Von Willebrand Factor Multimers: From Structure to Clinical Significance. Blood Rev. 2017.
Federici AB, Lee CA, Berntorp E, et al. Multicenter Clinical Trial of Recombinant Von Willebrand Factor in Type 3 Von Willebrand Disease Patients. Blood. 2019.
Chen YC, Chao TY, Lin WY, et al. Diagnosis Accuracy of Von Willebrand Factor Multimer Analysis in Type 2 VWD: A Systematic Review and Meta-Analysis. J Clin Lab Anal. 2022.
Medication Comparisons
Compare medications used to treat Absence Of Intermediate Von Willebrand Factor Multimers C5826356. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy