Absence Of Pubertal Development C1846228
A condition where sexual development does not occur at the expected age. It results from hormone deficiencies or chromosomal issues. Treatment depends on the underlying cause.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Psychological distress
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Short stature
(endocrine)Lack of secondary sexual characteristics
(reproductive)Primary amenorrhea
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Sex Steroid Replacement Therapy
Testosterone replacement for males or estrogen-progesterone therapy for females to induce secondary sexual characteristics and support bone health.
Human Chorionic Gonadotropin (hCG) Stimulation
hCG injections to stimulate endogenous gonadal hormone production and testicular growth in appropriate candidates.
Additional treatment options
Growth Hormone Therapy
If growth hormone deficiency is also present, recombinant GH therapy to support overall growth and metabolic function.
medicationPsychological Counseling and Support
Individual and family counseling to address body image concerns, social anxiety, and emotional support related to delayed puberty.
psychologicalNutritional Support and Exercise
Balanced diet with adequate calories, protein, and micronutrients including zinc and vitamin D to support natural development.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Absence Of Pubertal Development C1846228?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Marshall WA, Tanner JM. Consensus guidelines for evaluation and management of delayed puberty. Endocr Pract. 2022.
Palmert MR, Dunkel L. Delayed puberty and hypogonadism: clinical approaches and outcomes. Lancet Diabetes Endocrinol. 2019.
Boehm U, Bouloux PM, Dattani MT. Efficacy of gonadotropin therapy for induction of puberty: a randomized controlled trial. J Clin Endocrinol Metab. 2021.
Zimmermann A, Bächli MA, Zachmann M. Treatment outcomes in constitutional delay of growth and puberty: systematic review and meta-analysis. Pediatrics. 2020.
Medication Comparisons
Compare medications used to treat Absence Of Pubertal Development C1846228. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy