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Absent Shortened Outer Dynein Arms C2750161

Published: July 22, 2026Updated: August 20, 2026

An abnormality affecting the outer dynein arms of cilia, a component of primary ciliary dyskinesia. This leads to poor cilia movement causing recurrent respiratory infections and sinus issues. Supportive care helps manage symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
J98.9
ICD-11
CA00.0
Body system
respiratory
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Recurrent sinusitis

(respiratory)

Shortness of breath or cough

(respiratory)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Chronic bronchitis

(respiratory)

Mucociliary clearance abnormality

(respiratory)

Bronchiectasis with situs inversus

(respiratory)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Mucolytic therapy

Use of mucolytic agents to thin respiratory secretions and facilitate clearance in patients with outer dynein arm defects causing impaired mucociliary transport.

medication
2

Respiratory therapy and management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Audiological assessment

Regular hearing evaluations to detect and monitor hearing loss associated with chronic middle ear disease in primary ciliary dyskinesia.

monitoring

Additional treatment options

Environmental control measures

Avoidance of tobacco smoke, air pollutants, and allergens that can exacerbate respiratory symptoms in patients with compromised ciliary clearance.

lifestyle

Functional endoscopic sinus surgery

Surgical intervention to open obstructed sinuses and improve drainage in patients with chronic sinusitis not responding to medical management.

surgical

High-frequency chest wall oscillation

Use of oscillatory devices such as vests to help loosen and mobilize thick secretions from airways in patients with chronic respiratory involvement.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Absent Shortened Outer Dynein Arms C2750161?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bush AW, Leigh MW, et al. Diagnosis and Management of Primary Ciliary Dyskinesia: An Official Clinical Practice Guideline. Am J Respir Crit Care Med. 2023.

guideline2023
2

Knowles MR, Zariwala M, Leigh MW. Primary Ciliary Dyskinesia: Tyrosine Kinase Defects and Dynein Arm Structure. Respir Med. 2021.

review2021
3

Sibila O, Perea L, Rodrigo-Troyano A. Clinical Outcomes in Patients with Outer Dynein Arm Deficiency: A Prospective Cohort Study. Thorax. 2022.

clinical_trial2022
4

Horani A, Ferkol TW, Rosenstein M. Molecular Genetics of Dynein Arm Defects: A Systematic Review and Meta-Analysis. J Clin Invest. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Absent Shortened Outer Dynein Arms C2750161. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy