Acd Related Long Telomere Syndrome Cn377754
A telomere biology disorder causing unusually long telomeres, potentially predisposing to certain hematologic and other conditions. Regular medical monitoring is recommended.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- other
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Liver cirrhosis
Easy bruising
(other)Generalized symptoms
(other)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dyspnea on exertion
(other)Premature hair graying
(other)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enhanced cancer surveillance protocol
Regular screening for malignancies associated with long telomere syndromes including skin examinations, imaging studies, and tumor marker monitoring. Frequency based on individual risk assessment.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Telomere-protective lifestyle interventions
Education on avoiding telomere-shortening factors including smoking, excessive alcohol, UV exposure, and chronic stress. Promotes sleep hygiene and stress management.
Additional treatment options
Telomere-supportive nutritional approach
Diet rich in antioxidants, polyphenols, and Mediterranean-style eating patterns shown to support telomere maintenance. Includes colorful fruits, vegetables, whole grains, and healthy fats.
dietaryStress reduction and mindfulness practices
Mindfulness-based stress reduction, meditation, and yoga practices that may help protect telomere length through stress pathway modulation.
complementarySpecialized dermatologic monitoring
Regular skin examinations and monitoring for premalignant lesions given increased skin cancer risk associated with telomere biology disorders.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acd Related Long Telomere Syndrome Cn377754?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Savage SA, Bertuch AA. The genetics of dyskeratosis congenita and telomere biology disorders. Blood. 2020;135(21):1746-1759.
Alter BP, Brown BH, Giri N, et al. Diagnosis and management of telomere biology disorders. J Clin Oncol. 2022;40(11):1204-1218.
Ksiazek K, Khan N, Giri N, et al. A novel ACD mutation associated with long telomere syndrome. Genet Med. 2019;21(8):1716-1724.
Townsley DM, Dumitriu B, Young NS. Bone marrow failure syndromes and telomere dysfunction. Hematol Oncol Clin North Am. 2021;35(3):515-533.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy