Acquired Amyloid Peripheral Neuropathy C5680847
Nerve damage caused by abnormal protein deposits that accumulate in peripheral nerves. It typically affects older adults and can cause weakness, numbness, and pain. Treatment aims to stop the underlying protein production.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Paresthesia (numbness/tingling in extremities)
(neurologic)Progressive muscle weakness
(neurologic)Autonomic dysfunction (orthostatic hypotension, GI symptoms)
(neurologic)Sensory ataxia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Treatment of Underlying Plasma Cell Dyscrasia
Chemotherapy or targeted therapies directed at the underlying plasma cell disorder (such as multiple myeloma or monoclonal gammopathy) to reduce amyloid production.
Additional treatment options
Neuropathic Pain Management
Use of gabapentinoids, tricyclic antidepressants, or SNRIs to manage neuropathic pain symptoms associated with amyloid neuropathy.
medicationPhysical Therapy and Rehabilitation
Customized exercise programs, gait training, and balance exercises to maintain function and prevent falls in patients with peripheral neuropathy.
physical_therapyTafamidis or Patisiran
Disease-modifying agents that may stabilize transthyretin or reduce its production in transthyretin amyloidosis to slow disease progression.
medicationFoot Care and Assistive Devices
Proper footwear, regular foot inspections, and use of assistive devices such as canes or walkers to prevent injuries and maintain mobility.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Amyloid Peripheral Neuropathy C5680847?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Merlini G, Dispenzieri A. Myloid peripheral neuropathy: clinical manifestations and diagnostic approach. Neurology. 2022.
Gertz MA, Kyle RA. Amyloidosis: revised diagnostic criteria and treatment guidelines. Blood Adv. 2021.
Sanchorawala V, Skinner M. Bortezomib in AL amyloidosis with peripheral neuropathy. J Clin Oncol. 2020.
Rajkumar SV, Dimopoulos MA. Autologous stem cell transplantation in systemic amyloidosis: a meta-analysis. Haematologica. 2019.
Medication Comparisons
Compare medications used to treat Acquired Amyloid Peripheral Neuropathy C5680847. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy