Acquired Angioedema With C1inh Deficiency C5848086
A condition causing recurrent episodes of swelling, due to acquired deficiency of a protein called C1 inhibitor. Often seen in adults with underlying blood disorders. Treatment includes medications to control swelling and avoid triggers.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acquired angioedema
Swelling attacks
Laryngeal edema
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
GI tract swelling
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
C1 Esterase Inhibitor Therapy
Direct replacement of deficient C1 inhibitor protein through plasma-derived or recombinant products for acute attacks and prophylactic use.
Icatibant
Subcutaneous bradykinin antagonist providing rapid relief of swelling attacks by blocking bradykinin-mediated inflammatory pathways.
Additional treatment options
Long-term Prophylaxis
Regular administration of C1-INH concentrate or antifibrinolytic agents such as tranexamic acid to reduce attack frequency and severity.
medicationEmergency Preparedness
Maintaining ready access to attack medications, carrying medical alert documentation, and establishing clear communication with emergency medical services.
lifestyleStress Management Techniques
Incorporation of relaxation practices, mindfulness, and stress-reduction strategies that may help minimize attack triggers related to emotional factors.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Angioedema With C1inh Deficiency C5848086?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Cicardi M, Bork K, Caballero T, et al. Evidence-based recommendations for the therapeutic management of hereditary and acquired angioedema. Allergy. 2012.
Zuraw BL, Christiansen SC. Hereditary angioedema and acquired C1 inhibitor deficiency: pathophysiology and management. J Allergy Clin Immunol Pract. 2016.
Sabetta R, Perino A, Saponiero A, et al. Acquired angioedema with C1-inhibitor deficiency: clinical and immunologic characteristics and response to therapy. Clin Rev Allergy Immunol. 2019.
Craig TJ, Riedl MA, Yang WH, et al. Icatibant for treatment of acquired C1 inhibitor deficiency: an open-label study. Ann Allergy Asthma Immunol. 2015.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy