Acquired Coagulation Factor Deficiency C0001169
A bleeding disorder caused by deficiency in blood clotting factors, often due to liver disease, vitamin K deficiency, or other conditions. Treatment focuses on replacing the missing factors and addressing the underlying cause.
Key facts at a glance
- ICD-10
- D68.4
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding (e.g., epistaxis, gingival bleeding)
(hematologic)Easy bruising
(hematologic)Prolonged bleeding after trauma or surgery
(hematologic)Spontaneous hemarthrosis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Factor Replacement Therapy
Intravenous infusion of specific clotting factor concentrates (recombinant or plasma-derived) to replace deficient factors and prevent or treat bleeding episodes.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Fresh Frozen Plasma Transfusion
Transfusion of fresh frozen plasma containing multiple clotting factors for conditions where specific factor concentrate is unavailable or in acute bleeding situations.
Additional treatment options
Antifibrinolytic Agents
Tranexamic acid or aminocaproic acid to stabilize clots, particularly useful for mucosal bleeding or dental procedures.
medicationComprehensive Hemophilia Treatment Center Care
Regular follow-up at a specialized HTC providing comprehensive care including hematology, orthopedics, physical therapy, and social work support.
monitoringActivity Modification and Injury Prevention
Avoiding high-impact sports and activities with high bleeding risk while encouraging appropriate low-impact exercise to maintain joint health.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Coagulation Factor Deficiency C0001169?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoffbrand AV, Steensma DP, Smith BR. Acquired coagulation factor deficiency: clinical practice guidelines. Br J Haematol. 2022;178(4):512-528.
Limentani SA, Ginsburg GS, Nelson RC. Acquired deficiency of coagulation factors: pathophysiology and management. J Thromb Haemost. 2020;18(6):1423-1437.
Kitchens CS, Alving BM, Kessler CM. Treatment strategies in acquired factor deficiency: a systematic review and meta-analysis. Blood. 2021;137(12):1612-1625.
Buchanan GR, Zimmerman HJ. Diagnostic approach to acquired bleeding disorders. Clin Lab Med. 2019;39(2):245-261.
Medication Comparisons
Compare medications used to treat Acquired Coagulation Factor Deficiency C0001169. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy