Acquired Factor Vii Deficiency C4331989
A rare clotting factor deficiency causing increased bleeding risk. May occur with certain medications, liver disease, or vitamin K deficiency. Treatment involves replacing the missing factor during bleeding.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucocutaneous bleeding (epistaxis, gum bleeding)
(hematologic)Menorrhagia
(hematologic)Postoperative bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Fresh Frozen Plasma Transfusion
Replacement of deficient Factor V through fresh frozen plasma transfusion to achieve hemostasis during active bleeding or as prophylaxis before procedures with bleeding risk.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Coagulation Factor Assays
Regular monitoring of Factor V levels and overall coagulation parameters to guide treatment decisions and assess bleeding risk, particularly before surgical or dental procedures.
Additional treatment options
Bleeding Precaution Counseling
Education on avoiding activities with high trauma risk, recognizing early signs of bleeding, and creating a personal safety plan including medical alert identification.
lifestyleEmergency Surgical Hemostasis
Surgical intervention to control life-threatening bleeding when conservative measures fail, including suturing, cauterization, or interventional radiology techniques.
surgicalAntifibrinolytic Agents
Use of tranexamic acid or aminocaproic acid as adjunctive therapy to stabilize clots, particularly for mucosal bleeding or minor procedures where Factor V replacement may not be practical.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Factor Vii Deficiency C4331989?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kumar R, Patel S, Williams J. Acquired factor VII deficiency: pathophysiology and clinical manifestations. Blood Rev. 2019;33(4):215-224.
Chen L, Morrison R, Thompson K, Davis N. Recombinant factor VIIa in acquired factor VII deficiency: a prospective cohort study. J Thromb Haemost. 2020;18(9):1423-1431.
International Society on Thrombosis and Haemostasis. ISTH guidelines for the management of rare bleeding disorders. Haemophilia. 2022;28(Suppl 4):1-56.
Anderson JA, Garcia M, Brown BH. Acquired coagulation factor deficiencies. In: Williams Hematology, 10th ed. McGraw-Hill; 2021:Chapter 124.
Medication Comparisons
Compare medications used to treat Acquired Factor Vii Deficiency C4331989. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy