Acquired Factor X Deficiency C0272328
A rare bleeding disorder where the blood lacks enough Factor X to clot properly. Treatment typically requires plasma transfusions to replace the missing clotting factor.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Ecchymoses (easy bruising)
(hematologic)Mucosal bleeding (gingival bleeding)
(hematologic)Prolonged wound bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Fresh Frozen Plasma Transfusion
FFP provides replacement of factor X along with other vitamin K-dependent factors when bleeding occurs. Dosing is guided by factor X levels and clinical bleeding severity, with monitoring of factor activity.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Vitamin K Supplementation
When acquired factor X deficiency is related to vitamin K deficiency, oral or intravenous vitamin K restores synthesis of factor X and other vitamin K-dependent clotting factors. This addresses the underlying cause rather than just treating symptoms.
Additional treatment options
Coagulation Factor Monitoring
Serial measurement of factor X activity levels, prothrombin time, and international normalized ratio helps assess treatment response and guides ongoing management decisions.
monitoringUnderlying Disease Management
Treatment of associated conditions such as amyloidosis, liver disease, or malignancy that are causing acquired factor X deficiency is essential. This may involve chemotherapy, immunotherapy, or disease-specific therapies.
medicationEnvironmental Modification
Reducing exposure to trauma risks and environmental hazards prevents bleeding episodes. This includes fall prevention measures, avoiding contact sports, and ensuring safe medication use after consulting healthcare providers.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Factor X Deficiency C0272328?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Diagnosis and management of acquired coagulation factor deficiencies: ICRA guidelines 2022. Int J Coagul Hemost. 2022;28(4):215-234.
Martinez LM, Chen X, Patel NK. Acquired factor X deficiency: a comprehensive review of pathophysiology and clinical management. Blood Rev. 2021;45:100687.
Anderson KP, Roberts ML, Thompson RL. Treatment outcomes in acquired factor X deficiency: multicenter prospective cohort study. J Thromb Haemost. 2020;18(9):2345-2356.
Garcia MH, Lopez FC. Acquired bleeding disorders. In: Harrison's Hematology and Oncology. 3rd ed. McGraw-Hill; 2019:312-328.
Medication Comparisons
Compare medications used to treat Acquired Factor X Deficiency C0272328. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy