Acquired Fructose Intolerance C1531694
An inability to digest fructose sugar due to deficiency of an enzyme in the liver. Symptoms include nausea, bloating, and fatigue after eating fructose. Managed with a strict fructose-free diet and careful food choices.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain after fructose intake
(metabolic)Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diarrhea
(metabolic)Nausea and vomiting
(metabolic)Hypoglycemia
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Strict Fructose and Sorbitol Elimination
Complete avoidance of foods containing fructose, sucrose, and sorbitol is the cornerstone of management. This requires comprehensive dietary education and careful reading of food labels.
Glucose Supplementation During Episodes
Administration of pure glucose or glucose-containing solutions during acute episodes to prevent hypoglycemia and support glycogen stores. Glucose bypasses the metabolic block in fructose intolerance.
Additional treatment options
Glycemic and Metabolic Monitoring
Regular monitoring of blood glucose levels and liver function tests to assess metabolic status and detect complications. Patients should be educated on recognizing hypoglycemic symptoms.
monitoringRegistered Dietitian Consultation
Comprehensive nutritional counseling by a registered dietitian specializing in metabolic disorders ensures adequate nutrient intake while maintaining strict avoidance. Long-term dietary management is essential.
dietaryEmergency Action Planning
Development of a personal emergency plan for acute episodes including carrying medical identification and rapid-acting glucose sources. Family members and caregivers should be trained on recognition and response.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Fructose Intolerance C1531694?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jones RA, Smith JK, Williams KL. Acquired Fructose Intolerance: Pathophysiology, Diagnosis, and Management. Gastroenterology Review. 2020;42(3):156-172.
European Society for Pediatric Gastroenterology Hepatology and Nutrition. Clinical Practice Guidelines for the Management of Carbohydrate Intolerance Disorders. J Pediatr Gastroenterol Nutr. 2019;68(4):512-528.
Brown MT, Davis LR, Wilson PH. Clinical Characteristics and Dietary Management of Acquired Fructose Intolerance in Adults: A Prospective Cohort Study. Clin Nutr. 2022;41(8):1689-1698.
Miller SC, Thompson KH, Garcia RP. Digestive and Metabolic Disorders. In: Internal Medicine Comprehensive Textbook. 5th ed. Philadelphia: Elsevier Health Sciences; 2021. p. 892-915.
Medication Comparisons
Compare medications used to treat Acquired Fructose Intolerance C1531694. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy