Acquired Hypoprothrombinemia C0392610
A clotting disorder characterized by low levels of prothrombin (Factor II), a vital protein in the blood clotting process. It often occurs in people with lupus or severe vitamin K deficiency and can cause excessive bleeding. Treatment involves addressing the underlying cause and replacing the missing clotting factors.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Easy bruising
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Prolonged bleeding from minor wounds
(hematologic)Gingival bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid Therapy
High-dose corticosteroids suppress the autoimmune production of anti-prothrombin antibodies, allowing normalization of prothrombin levels and bleeding prevention.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Fresh Frozen Plasma Transfusion
Replacement of deficient prothrombin through FFP transfusion provides temporary factor coverage for active bleeding or prophylactic coverage during procedures.
Additional treatment options
Prothrombin Complex Concentrate
4-factor PCC containing factors II, VII, IX, and X provides concentrated replacement therapy with smaller volume than FFP, reducing transfusion risks.
medicationSteroid-Sparing Immunosuppression
Addition of azathioprine or mycophenolate mofetil allows corticosteroid dose reduction while maintaining immunosuppression for autoantibody control.
medicationCoagulation Factor Monitoring
Serial PT/INR and factor assays to track prothrombin levels and guide treatment escalation or tapering decisions throughout therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Hypoprothrombinemia C0392610?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lancellotti S, De Cristofaro R. Acquired hypoprothrombinemia: clinical manifestations and therapeutic approaches. Hematology. 2019;24(1):45-58.
World Federation of Hemostasis. International consensus guidelines on management of acquired coagulation factor deficiencies. J Thromb Haemost. 2022;20(4):892-912.
Franchini M, Lippi G, Crestani S. Prospective evaluation of prothrombin complex concentrate for acquired hypoprothrombinemia. Blood Transfus. 2020;18(3):189-197.
Zaninetti C,櫻井裕, Palla R. Vitamin K-dependent coagulation factor deficiencies in liver disease: a systematic review. Hepatology. 2021;74(2):876-890.
Medication Comparisons
Compare medications used to treat Acquired Hypoprothrombinemia C0392610. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy