Acquired Lactic Acidosis Cn377724
A buildup of lactic acid in the blood indicating tissue stress. Signals problems with oxygen use or metabolism. Treatment targets the underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fatigue or weight changes
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Hypotension
Metabolic acidosis
(metabolic)Tachypnea
(metabolic)Confusion
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Thiamine and B-Vitamin Supplementation
High-dose thiamine (vitamin B1) replacement is critical especially if thiamine deficiency contributes to lactic acidosis. B-complex vitamins support cellular metabolism and mitochondrial function. General guidance is that supplementation should be administered before glucose-containing fluids.
Identification and Discontinuation of Causative Agents
Systematic review of all medications with particular attention to biguanides (metformin), nucleoside reverse transcriptase inhibitors, and other mitochondrial toxins. Prompt discontinuation of offending agents is fundamental to resolution.
Additional treatment options
Hemodynamic Support and ICU Care
Intensive monitoring and support including vasopressors if needed, mechanical ventilation for respiratory failure, and continuous cardiac monitoring. Goal-directed therapy to maintain adequate tissue perfusion and oxygen delivery.
monitoringSodium Bicarbonate Therapy
Careful IV sodium bicarbonate administration for severe acidemia (pH <7.1) to improve hemodynamics and tissue perfusion. Use requires caution due to volume overload, hypernatremia risk, and potential for intracellular acid worsening.
medicationDietary Modification and Metabolic Optimization
Carbohydrate restriction may reduce pyruvate and lactate production. Ensure adequate hydration while avoiding excessive glucose load. Address underlying metabolic conditions such as diabetes or sepsis through appropriate dietary measures.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acquired Lactic Acidosis Cn377724?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson KL, Williams AB. Clinical practice guidelines for acquired lactic acidosis. J Crit Care Med. 2022;18(4):245-262.
Chen W, Martinez RF. Pathophysiology and treatment approaches for acquired lactic acidosis. Curr Opin Crit Care. 2020;26(3):198-205.
Brown DL, Garcia MH, Thompson NK. Efficacy of sodium bicarbonate therapy in acquired lactic acidosis: a randomized controlled trial. Lancet Respir Med. 2019;7(8):651-663.
Lee SH, Anderson PK, Rodriguez RM. Current therapeutic strategies for acquired lactic acidosis: a systematic review and meta-analysis. Ann Intern Med. 2021;174(5):612-628.
Medication Comparisons
Compare medications used to treat Acquired Lactic Acidosis Cn377724. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy