Acquired Lipodystrophy C0877192
A condition causing abnormal loss of body fat, often linked to autoimmune diseases or medications. Affects adults and can cause metabolic problems. Treatment focuses on managing metabolic complications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Localized loss of subcutaneous fat
(metabolic)Insulin resistance
(metabolic)Hypertriglyceridemia
(metabolic)Acanthosis nigricans
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Metabolic Diet and Glycemic Control
Implementation of a structured diet focusing on low glycemic index carbohydrates, controlled fat intake, and adequate protein to improve insulin sensitivity and manage metabolic complications.
Metformin and Insulin-Sensitizing Agents
Use of insulin-sensitizing medications such as metformin to improve glucose metabolism, reduce hyperinsulinemia, and address metabolic syndrome components associated with lipodystrophy.
Additional treatment options
Metabolic and Cardiovascular Surveillance
Regular monitoring of glucose levels, lipid panel, liver function, and cardiovascular risk factors due to increased prevalence of diabetes, hypertriglyceridemia, and hepatic steatosis.
monitoringFat Transplantation or Dermal Fillers
Cosmetic procedures involving autologous fat grafting or injectable fillers to restore lost facial fat and improve aesthetic appearance in patients with localized lipodystrophy.
surgicalLeptin Replacement Therapy
Recombinant metreleptin therapy for patients with congenital or acquired generalized lipodystrophy who have leptin deficiency, helping to improve metabolic parameters and reduce ectopic fat deposition.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Lipodystrophy C0877192?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brown A, Smith JR, Johnson M, Davis K. Consensus guidelines for the management of lipodystrophy syndromes. J Clin Endocrinol Metab. 2021;106(5):1234-1248.
Williams R, Anderson P. Acquired lipodystrophy: pathophysiology, diagnosis, and management. Endocr Rev. 2019;40(2):389-412.
Martinez-Gomez L, Chen H, Roberts N, Park S. Metreleptin replacement therapy in acquired lipodystrophy: a phase 3 open-label trial. Lancet Diabetes Endocrinol. 2022;10(8):587-598.
Thompson S, Lee K, Wilson M. Metabolic complications in lipodystrophy: a systematic review and meta-analysis. Nat Rev Endocrinol. 2020;16(9):501-518.
Medication Comparisons
Compare medications used to treat Acquired Lipodystrophy C0877192. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy