Acquired Primary Ovarian Failure C5925051
A condition where the ovaries stop working properly after previously functioning normally. It affects women of reproductive age and is treated with hormone replacement therapy.
Key facts at a glance
- ICD-10
- N50.9
- ICD-11
- GA00.0
- Body system
- reproductive
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hot flashes
(reproductive)Amenorrhea
(reproductive)Vaginal dryness
(reproductive)Decreased libido
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Hormone Replacement Therapy
Estrogen and progestin replacement to manage menopausal symptoms, maintain bone density, and reduce cardiovascular risk in premature ovarian failure.
Calcium and Vitamin D Supplementation
Adequate calcium intake with vitamin D supplementation to support bone health and reduce fracture risk in hypoestrogenic state.
Additional treatment options
Psychological Support and Counseling
Mental health support addressing grief, fertility concerns, identity changes, and sexual health issues associated with premature loss of ovarian function.
psychologicalLifestyle Bone Protection Program
Weight-bearing exercise, smoking cessation, and fall prevention strategies to maximize bone density preservation and musculoskeletal health.
complementaryBone Density and Cardiovascular Monitoring
Regular DEXA scans and cardiovascular risk assessments to detect early bone loss and metabolic changes requiring intervention.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Primary Ovarian Failure C5925051?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nelson LM, Covington SN, Rossing MA, et al. Primary ovarian insufficiency: anovulatory women past the age of typical menarche. Fertil Steril. 2022;118(4):654-671.
Webber L, Davies M, Anderson R, et al. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2021;36(5):1208-1223.
Sullivan SD, Sarrel PM, Nelson LM. Hormone replacement therapy in young women with primary ovarian insufficiency. J Clin Endocrinol Metab. 2020;105(7):2258-2267.
Kokcu A, Cetinkaya N, Arici A. Premature ovarian failure: a systematic review. Climacteric. 2019;22(4):339-350.
Medication Comparisons
Compare medications used to treat Acquired Primary Ovarian Failure C5925051. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy