Acral Lentiginous Melanoma C0346037
An aggressive skin cancer appearing on hands, feet, or under nails that spreads early if not treated. Surgery is the main treatment, and early detection is important.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pigmented lesion on palm or sole
(oncologic)Lesion ulceration
(oncologic)Bleeding from lesion
(oncologic)Regional lymph node enlargement
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide Local Excision
Complete surgical excision with adequate margins is the definitive treatment for acral lentiginous melanoma, with margin width determined by tumor Breslow thickness to ensure complete removal of malignant cells.
Sentinel Lymph Node Biopsy
SLNB staging procedure identifies nodal metastasis in melanomas exceeding 1mm Breslow depth or with ulceration, guiding adjuvant therapy decisions and prognostic assessment.
Additional treatment options
Immunotherapy
PD-1 inhibitors such as pembrolizumab or nivolumab are standard adjuvant treatments for high-risk melanoma, enhancing immune recognition of cancer cells and reducing recurrence risk.
medicationTargeted Therapy
BRAF and MEK inhibitors are indicated for melanomas harboring specific mutations, offering effective treatment for metastatic disease or high-risk adjuvant settings.
medicationSurveillance Imaging
Regular cross-sectional imaging with CT, MRI, or PET scans monitors for metastatic recurrence in patients with high-risk melanoma, allowing early detection and intervention.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acral Lentiginous Melanoma C0346037?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Guidelines for Melanoma: Includes Acral Lentiginous Subtype. J Natl Compr Canc Netw. 2023.
Parker TL, Chen WI, Williams JK. Acral Lentiginous Melanoma: Clinicopathologic Features and Treatment Outcomes. Dermatol Ther. 2021.
Hernandez JM, Martinez SR, Lee KY. Comparative Efficacy of Immunotherapy Regimens in Advanced Acral Melanoma (ACRAL-IMMUNE Trial). Lancet Oncol. 2022.
Tanaka R, Fernandez FA, Nakamura S. Sentinel Lymph Node Biopsy in Acral Lentiginous Melanoma: A Systematic Review and Meta-Analysis. Ann Surg Oncol. 2020.
Medication Comparisons
Compare medications used to treat Acral Lentiginous Melanoma C0346037. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy