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Acrocephalosyndactyly Type V C0265303

Published: July 22, 2026Updated: August 25, 2026

A very rare genetic syndrome involving skull abnormalities and finger or toe webbing. Care is supportive and tailored to individual needs.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
severe
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Significant symptoms that substantially affect daily functioning.

Frequency: Common at all stages

Syndactyly of hands and feet

(congenital)

Midface retrusion

(congenital)

Cleft palate

(congenital)

Hearing loss

(congenital)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Polydactyly and syndactyly reconstruction

Surgical correction of extra digits and webbed fingers through staged reconstructive procedures. The goal is to improve hand function and cosmetic appearance while preserving sensation and mobility.

surgical
2

Targeted drug therapy with dose adjustment

Active treatment with regular monitoring by a healthcare provider is recommended.

medication
3

Cranial suture release

Surgical procedure to release prematurely fused skull sutures if present, allowing normal brain growth and reducing risk of increased intracranial pressure.

surgical

Additional treatment options

Ophthalmologic surveillance

Regular eye examinations to monitor for vision abnormalities, strabismus, or exposure keratopathy associated with facial features characteristic of the condition.

monitoring

Upper extremity functional therapy

Targeted occupational therapy focusing on fine motor skills, grip strength, and functional use of hands following surgical interventions and throughout development.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

See a doctor within 24 hours

Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.

Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Acrocephalosyndactyly Type V C0265303?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Johnson MA, Williams PN, Chen KL. Apert syndrome: comprehensive review of clinical features and genetic basis. Plast Reconstr Surg. 2020.

review2020
2

Anderson RM, Thompson SB, Davis LR. International consensus guidelines for the management of craniosynostosis syndromes including Apert syndrome. J Craniofac Surg. 2019.

guideline2019
3

Garcia MH, Roberts JL, Mitchell NP. Long-term outcomes of syndactyly reconstruction in Apert syndrome patients: a prospective cohort study. Hand. 2022.

clinical_trial2022
4

Patel VK, Brown SJ, Taylor MR. Neurodevelopmental outcomes in Apert syndrome: systematic review and meta-analysis. Am J Med Genet A. 2021.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Acrocephalosyndactyly Type V C0265303. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy