Acth Producing Pituitary Gland Adenoma C1306214
A benign tumor of the pituitary gland that secretes ACTH, overstimulating the adrenal glands and causing Cushing's disease. Most common in adults. Treated with surgery to remove the tumor, radiation, or medications to control cortisol.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Visual field defect
Headache
Cushingoid features
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hyperpigmentation
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Transsphenoidal Adenomectomy
Endoscopic or microscopic surgical removal of the ACTH-secreting pituitary adenoma through the sphenoid sinus. This is the first-line treatment for most ACTH-producing pituitary adenomas.
Additional treatment options
Pituitary-Directed Medical Therapy
Use of pasireotide, cabergoline, or other pituitary-targeted agents to suppress ACTH secretion when surgery is unsuccessful, contraindicated, or as preoperative bridging.
medicationStereotactic Radiosurgery
Focused radiation therapy targeting the pituitary tumor for residual or recurrent disease after surgery. Achieves tumor control and biochemical remission in majority of patients.
procedureBilateral Adrenalectomy
Surgical removal of both adrenal glands as salvage therapy when pituitary surgery and medical management fail. Achieves immediate control of hypercortisolism.
surgicalPostoperative Endocrine Testing
Serial measurement of cortisol, ACTH, and pituitary hormones after treatment to detect remission, recurrence, or development of Nelson syndrome.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Acth Producing Pituitary Gland Adenoma C1306214?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nieman LK, Biller BM, Findling JW, et al. Treatment of Cushing's syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015.
Molitch ME. Diagnosis and treatment of pituitary adenomas: A review. JAMA. 2017.
Colao A, Petersenn S, Newell-Price J, et al. A 12-month phase 3 study of pasireotide in Cushing's disease. N Engl J Med. 2012.
Pivonello R, De Leo M, Cozzolino A, Colao A. The treatment of Cushing's disease: From molecular biology to surgery. Endocr Rev. 2018.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy