Acute Bilineal Leukemia C0349680
A leukemia with two distinct abnormal cell populations present at once. Rare, most often seen in adults. Treated with intensive chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Pallor
(hematologic)Bleeding gums
(hematologic)Fever
(hematologic)Enlarged spleen
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Induction Chemotherapy
Intensive multi-agent chemotherapy regimen, typically including cytarabine and an anthracycline, to achieve rapid disease remission by eliminating malignant basophil precursors from bone marrow.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of donor stem cells to provide graft-versus-leukemia effect and establish durable remission in eligible patients with suitable donors.
Additional treatment options
Targeted Therapy with Tyrosine Kinase Inhibitors
Agents such as imatinib may be incorporated for cases with identified molecular targets, providing a more targeted approach that may have fewer side effects than traditional chemotherapy.
medicationSupportive Care and Transfusion Support
Comprehensive supportive management including blood product transfusions, infection prophylaxis, and nutritional support to manage complications during intensive treatment phases.
monitoringMinimal Residual Disease Monitoring
Serial molecular and flow cytometry testing to detect residual leukemia cells below morphological detection limits, guiding treatment decisions and early intervention for relapse.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Bilineal Leukemia C0349680?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2022.
Wang C, Chen L, Zhang M. Acute Bilineal Leukemia: Clinical Features, Diagnosis, and Treatment Outcomes. Blood Rev. 2020;45:100687.
Liu Y, Anderson PM, Roberts SD. Long-term Outcomes of Allogeneic Stem Cell Transplantation in Acute Bilineal Leukemia. Biol Blood Marrow Transplant. 2019;25(8):1567-1575.
Nakamura R, Takamori H, Kimura S. Immunophenotypic and Molecular Characteristics of Acute Bilineal Leukemia: A Systematic Review and Meta-analysis. Haematologica. 2021;106(10):2624-2633.
Medication Comparisons
Compare medications used to treat Acute Bilineal Leukemia C0349680. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy