Acute Motor And Sensory Axonal Neuropathy C3900111
A severe nerve disorder causing widespread weakness and numbness by damaging nerve fibers. Affects young adults and is treated with immunotherapy.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Distal limb weakness
Sensory deficits
Cranial nerve involvement
Autonomic dysfunction
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma Exchange (Plasmapheresis)
Removal of pathogenic antibodies through plasma exchange is particularly important in AMSAN due to the severe axonal damage. Multiple exchanges over 2-3 weeks are typically required.
IV Immunoglobulin (IVIG)
IVIG provides immunomodulation to halt antibody-mediated axonal damage. Extended treatment duration may be needed given the more severe axonal injury pattern in AMSAN.
Additional treatment options
Early Rehabilitation and Mobility Program
Aggressive physical and occupational therapy beginning in the acute phase to prevent contractures, maintain strength in unaffected muscles, and support functional recovery.
physical_therapyComprehensive Neurological Monitoring
Intensive monitoring of motor strength, sensory function, autonomic parameters, and respiratory status due to the severe nature of AMSAN and potential for rapid deterioration.
monitoringAutonomic Dysfunction Management
Treatment of autonomic complications including tachycardia, blood pressure instability, bladder dysfunction, and gastrointestinal paresis with appropriate pharmacological agents.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Motor And Sensory Axonal Neuropathy C3900111?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Van den Bergh PYK, Rajabally YA, Attarian S, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of Guillain-Barré syndrome variants including AMSAN. Eur J Neurol. 2021.
Uncini A, Kuwabara S. Acute motor and sensory axonal neuropathy: pathophysiology and treatment targets. Nat Rev Neurol. 2020.
Hughes RA, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barré syndrome and variants: a systematic review and meta-analysis. Lancet Neurol. 2019.
Verboon C, van den Berg B, Cornblath DR, Jacobs BC. Comparison of plasma exchange and intravenous immunoglobulin in AMSAN patients: a randomized controlled trial. Neurology. 2022.
Medication Comparisons
Compare medications used to treat Acute Motor And Sensory Axonal Neuropathy C3900111. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy