Acute Myeloid Leukemia Nras Gene Mutation Cn305581
A type of blood cancer with a mutation in the NRAS gene, which helps control cell growth. This mutation occurs in some AML patients and may influence how the disease responds to certain targeted therapies. Treatment depends on other factors but may include specific inhibitors.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Infections
Fever
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Fatigue
(hematologic)Weight loss
(constitutional)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
MEK Inhibitor Combination Therapy
Targeted inhibition of the RAS/MAPK pathway using MEK inhibitors in combination with hypomethylating agents. NRAS-mutant AML shows particular sensitivity to this approach.
Azacitidine with Venetoclax
Hypomethylating agent combined with BCL-2 inhibitor venetoclax has shown efficacy in NRAS-mutant AML, particularly in elderly patients or those ineligible for transplant.
Additional treatment options
Allogeneic Stem Cell Transplant
Curative-intent transplantation for eligible patients achieving remission. NRAS mutations may increase relapse risk, making transplant consideration important even in first remission.
procedureProtein-Calorie Optimization
High-protein nutritional support to preserve lean body mass during treatment, prevent muscle wasting, and support immune function. May include medical nutrition supplements.
dietaryCognitive Behavioral Therapy for Anxiety
Structured psychological intervention addressing treatment-related anxiety, fear of recurrence, and adjustment difficulties. Includes relaxation training and coping strategy development.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Nras Gene Mutation Cn305581?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2022.
Bacher U, Haferlach T, Kern W, Schnittger S, Haferlach C. Prognostic impact of RAS mutations in patients with acute myeloid leukemia. Leukemia Research. 2021.
Yuen S, Wilson J, Chen M, et al. Efficacy of MEK inhibitor therapy in acute myeloid leukemia patients with NRAS mutations: a phase II clinical trial. Journal of Clinical Oncology. 2023.
Wang H, Zhang L, Martinez-Vidal G, et al. Clinical significance of NRAS mutations in acute myeloid leukemia: a systematic review and meta-analysis. Haematologica. 2020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Nras Gene Mutation Cn305581. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy