Acute Myeloid Leukemia T 1 22 Cn305552
A blood cancer with a specific chromosomal change involving chromosomes 1 and 22. This translocation is more commonly found in infants and young children. It is often associated with a type of AML involving abnormal megakaryocytes.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising or bleeding
(hematologic)Fever
(hematologic)Bone pain
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Therapy
High-dose chemotherapy protocol combining cytarabine with an anthracycline to induce complete remission. Standard approach for medically fit patients with core-binding factor AML.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
High-Dose Cytarabine Consolidation
Repeated cycles of high-dose cytarabine following induction, which is particularly effective for core-binding factor leukemias. Offers good outcomes without transplant for standard-risk patients.
Additional treatment options
Gemtuzumab Ozogamicin Addition
CD33-directed antibody-drug conjugate added to standard chemotherapy for eligible patients. Targets leukemic cells expressing CD33 antigen with improved outcomes in favorable-risk AML.
procedureTargeted Therapy for KIT Mutations
If KIT mutation is present, tyrosine kinase inhibitors may be incorporated into treatment strategy. Still under investigation but shows promise for improving outcomes in this subset.
medicationPsychological Support Services
Integrated mental health support including counseling and coping strategies for patients and families facing AML diagnosis. Addresses anxiety, depression, and treatment adherence.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 1 22 Cn305552?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017.
Kantarjian H, Kadia T, DiNardo C, Daver N, Borthakur G, Jabbour E, et al. Acute myeloid leukemia: current paradigm and novel therapies. CA Cancer J Clin. 2021.
Wei AH, Montesinos P, Ivanov V, DiNardo CD, Novak J, Yoon SS, et al. Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial. Blood. 2020.
Zhu C, Liu Y, Wang S, Li X, Sun Q, Chen F, et al. Hypomethylating agents combined with venetoclax for AML: a systematic review and meta-analysis. Lancet Haematol. 2023.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 1 22 Cn305552. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy