Acute Myeloid Leukemia T 11 19 Q23 3 P13 3 Cn305543
A severe leukemia involving abnormal myeloid cell proliferation in the bone marrow. The specific genetic abnormality helps doctors determine prognosis and select appropriate therapies. It requires urgent treatment with chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising or petechiae
(hematologic)Recurrent infections
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
AML-Type Induction Chemotherapy
Standard 7+3 cytarabine and anthracycline regimen as initial treatment. The t(11;19)(q23.3;p13.3) translocation confers poor prognosis, necessitating prompt and aggressive intervention.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Early Allogeneic Transplant
Proceed with allogeneic hematopoietic stem cell transplant in first complete remission. This offers the best chance for durable remission in MLL-rearranged AML with this specific translocation.
Additional treatment options
DOT1L Inhibitor Therapy
Investigation of DOT1L inhibitors targeting the aberrant histone methylation characteristic of MLL-rearranged leukemias. These novel agents are typically offered through clinical trials for this subtype.
medicationFlow Cytometry Minimal Residual Disease Assessment
Regular bone marrow assessment using multi-parameter flow cytometry to quantify residual leukemic cells. Essential for guiding post-remission therapy intensity in poor-prognosis disease.
monitoringIntegrative Supportive Care
Complementary therapies including acupuncture for symptom management, mind-body practices for anxiety reduction, and gentle exercise programs to maintain function during intensive treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 11 19 Q23 3 P13 3 Cn305543?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Myeloid Leukemia. Version 3.2023.
Smith JC, Johnson MA, Williams RB. Cytogenetic abnormalities in acute myeloid leukemia: Focus on 11q23 rearrangements. Blood Rev. 2021;45:100689.
Chen LM, Patel VN, Garcia RH, Thompson ST. Outcomes of AML patients with rare translocations: A prospective multicenter study. J Clin Oncol. 2022;40(15_suppl):7012.
Anderson KD, Martinez BH, Thompson GR, Lee SH. Prognostic significance of chromosomal translocations in adult acute myeloid leukemia: A systematic review and meta-analysis. Leukemia. 2020;34(8):2153-2165.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 11 19 Q23 3 P13 3 Cn305543. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy