Acute Myeloid Leukemia T 11 19 Q23 P13 1 Cn305542
A severe blood disorder where abnormal bone marrow cells interfere with normal blood cell production. This variant has specific genetic features that help guide treatment planning. It occurs across age groups and requires prompt medical care.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising or petechiae
(hematologic)Recurrent infections
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Induction Chemotherapy
Aggressive cytarabine and anthracycline-based induction therapy targeting rapid leukemic cell reduction. MLL rearrangements like t(11;19) typically require more intensive approaches due to poor response to standard protocols.
Allogeneic Stem Cell Transplantation
Proceed to transplant evaluation early as MLL-rearranged AML carries high relapse risk. The procedure involves conditioning chemotherapy followed by donor stem cell infusion to establish new hematopoiesis.
Additional treatment options
Histone Deacetylase Inhibitors
Epigenetic modifying agents such as vorinostat may be combined with standard therapy to target the aberrant chromatin remodeling characteristic of MLL-rearranged leukemias.
medicationSerial Molecular Monitoring
Quantitative PCR monitoring for MLL rearrangements to detect molecular relapse before hematologic recurrence. Allows for preemptive intervention strategies.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 11 19 Q23 P13 1 Cn305542?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017.
Meyer C, Burmeister T, Gröger D, et al. The KMT2A recombinome of acute leukemias bearing 11q23 translocations. Leukemia. 2018.
Khan N, Perl AE, Martinelli G, et al. Clinical outcomes in patients with relapsed/refractory KMT2A-rearranged acute myeloid leukemia treated with targeted therapy. J Clin Oncol. 2022.
Sun Y, Jiang A, Zhang J, et al. Prognostic significance of 11q23/KMT2A translocations in adult acute myeloid leukemia: a systematic review and meta-analysis. Haematologica. 2020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 11 19 Q23 P13 1 Cn305542. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy