Acute Myeloid Leukemia T 15 17 Q24 Q21 Cn305533
A subtype of blood cancer caused by an exchange of genetic material between chromosomes 15 and 17. Also called APL. This genetic change allows for targeted treatment with excellent response rates.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Easy bruising
(hematologic)Frequent infections
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
ATRA and Arsenic Trioxide Combination
All-trans retinoic acid combined with arsenic trioxide represents the standard first-line therapy for APL, inducing differentiation of malignant promyelocytes into mature cells.
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
ATRA with Anthracycline Consolidation
ATRA-based therapy with anthracycline consolidation for high-risk patients or those without access to arsenic trioxide, maintaining differentiation-based treatment approach.
Additional treatment options
Supportive Care with Transfusion Support
Component transfusion therapy including platelets and plasma to manage coagulopathy complications while disease-directed therapy takes effect.
procedureCoagulation Parameter Surveillance
Frequent monitoring of PT, PTT, fibrinogen, and D-dimer to detect and prevent hemorrhagic or thrombotic complications characteristic of APL coagulopathy.
monitoringMolecular Remission Monitoring
PCR-based detection of PML-RARA transcript to confirm molecular remission and detect early relapse, guiding duration of maintenance therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 15 17 Q24 Q21 Cn305533?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010.
Sanz MA, Fenaux P, Tallman MS, et al. Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet. Blood. 2019.
Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013.
Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 15 17 Q24 Q21 Cn305533. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy