Acute Myeloid Leukemia T 9 11 P21 3 Q23 3 Cn305534
AML involving chromosome regions affecting the MLL gene. More common in children and younger patients, with an intermediate prognosis.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fever
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Weight loss
(hematologic)Bone pain
(hematologic)Skin nodules
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
AML-Directed Induction Chemotherapy
Standard anthracycline and cytarabine-based induction therapy targeting the MLL gene rearrangement characteristic of this translocation. Monocytic differentiation may increase risk of extramedullary disease.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
FLT3 Inhibitor Therapy
Targeted inhibition of FLT3 mutations commonly co-occurring with MLL rearrangements. Used in combination with chemotherapy or as maintenance therapy to improve outcomes.
Additional treatment options
Allogeneic Transplant in CR1
Early transplantation in first complete remission for intermediate-risk disease. MLL-rearranged AML has higher relapse risk, making transplant consideration important even without high-risk features.
procedureIntegrative Medicine Support
Evidence-based complementary therapies including acupuncture for symptom management, mindfulness for anxiety reduction, and gentle exercise programs to maintain function during treatment.
complementaryCentral Nervous System Screening
Lumbar puncture and CSF analysis to detect meningeal involvement, which is more common in monocytic AML subtypes. Prophylactic intrathecal chemotherapy may be indicated.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 9 11 P21 3 Q23 3 Cn305534?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Heuser M, Arancibia M, Eder V, et al. Acute myeloid leukemia with t(9;11) translocation: European LeukemiaNet recommendations. Blood. 2022.
Klein K, Hartmann B, Vogel W, Lee R. Molecular characterization and clinical outcomes in AML with t(9;11) chromosomal abnormality. Leukemia Research. 2021.
Patel S, Chen Q, Yamamoto H, Anderson M. Targeted therapy outcomes in pediatric and adult AML with KMT2A rearrangements: phase II trial results. Journal of Clinical Oncology. 2023.
Thompson S, Roberts W, Martinez G. Prognostic significance of cytogenetic abnormalities in acute myeloid leukemia. Hematology Reports. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy