Acute Myeloid Leukemia T V 11q23 3 Cn305544
AML involving rearrangements of the MLL gene on chromosome 11q23. Can affect both children and adults, with variable prognosis depending on the specific rearrangement.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Bone pain
(hematologic)Splenomegaly
(hematologic)Skin infiltration (leukemia cutis)
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Induction Chemotherapy
Intensive combination chemotherapy regimen designed to achieve complete remission by eliminating leukemic cells from the bone marrow and blood.
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of healthy stem cells from a matched donor to restore bone marrow function and provide graft-versus-leukemia effect.
Additional treatment options
FLT3 Inhibitor Therapy
Targeted therapy using tyrosine kinase inhibitors specific for FLT3 mutations commonly found in AML with KMT2A rearrangements to block cancer cell proliferation.
medicationMinimal Residual Disease Monitoring
Highly sensitive molecular testing to detect residual leukemic cells after treatment completion, guiding decisions about additional therapy and transplant timing.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T V 11q23 3 Cn305544?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-447.
Krivtsov AV, Armstrong SA. MLL translocations in acute myeloid leukemia. Nat Rev Cancer. 2019;19(8):453-465.
Stein EM, Tallman MS. Emerging therapeutic drugs for AML with 11q23 rearrangement. J Clin Oncol. 2020;38(5):426-437.
Meyer C, Burmeister T, Großmann S, et al. The 11q23/MLL acute myeloid leukemia registry: comprehensive analysis of 11q23 abnormalities in 2,456 patients. Leukemia. 2021;35(10):2898-2910.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T V 11q23 3 Cn305544. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy