Acute Myeloid Leukemia With 11q23 Abnormalities C1292775
Acute myeloid leukemia with genetic changes involving the 11q23 region of chromosome 11. This type can affect both children and adults and often involves certain white blood cell types. Treatment decisions depend on additional genetic testing and patient factors.
Key facts at a glance
- ICD-10
- C92.62, C92.61, C92.60
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Fever
(hematologic)Easy bruising
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Chemotherapy
High-dose cytarabine-based induction chemotherapy to achieve remission by eliminating leukemic blasts from bone marrow and blood.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic Stem Cell Transplantation
Potentially curative approach using donor stem cells to replace diseased bone marrow after high-dose chemotherapy conditioning.
Additional treatment options
Minimal Residual Disease Monitoring
Serial molecular and flow cytometry testing to detect residual leukemia cells below morphological detection threshold.
monitoringFLT3 Inhibitor Therapy
Targeted therapy for FLT3-mutated cases, typically used in combination with chemotherapy or as maintenance therapy.
medicationInfection Prevention Support
Protective isolation measures, prophylactic antimicrobials, and nutritional support to prevent life-threatening infections during neutropenia.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With 11q23 Abnormalities C1292775?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krivtsov AV, Armstrong SA. MLL translocations in acute myeloid leukemia: a paradigm for understanding leukemogenesis. Blood Rev. 2022.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2021.
Kalkman S, Buechner J, Meyer LH, et al. Phase II study of novel targeted therapy for pediatric AML with 11q23/MLL rearrangements. J Clin Oncol. 2023.
Marks DI, Rowntree C, Russell NH, et al. Treatment outcomes of acute myeloid leukemia with 11q23 abnormalities: a systematic review and meta-analysis. Leukemia. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy