Acute Myeloid Leukemia With Cbfa2t3 Glis2 Fusion Cn379604
A rare genetic subtype of acute myeloid leukemia involving a fusion of the CBFA2T3 and GLIS2 genes. It is more commonly diagnosed in children and tends to be aggressive. Treatment typically involves intensive chemotherapy and may include stem cell transplant.
Key facts at a glance
- ICD-10
- C92.61, C92.62, C92.A1
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Fever
(hematologic)Easy bruising
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Early Allogeneic Stem Cell Transplant
Considered for eligible patients given the poor prognosis, with transplant ideally performed during first remission when patient is most fit.
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
Intensive AML Chemotherapy
Full-dose cytarabine and anthracycline-based induction and consolidation therapy to achieve morphological remission prior to transplant.
Additional treatment options
Intensive Minimal Residual Disease Testing
Frequent molecular monitoring using fusion-specific PCR to guide treatment intensification or de-escalation decisions.
monitoringClinical Trial Participation
Enrollment in clinical trials evaluating novel agents, immunotherapies, or targeted approaches specific to this rare fusion.
complementaryPediatric Oncology Support Services
Comprehensive psychosocial support addressing the significant emotional impact of poor-prognosis AML on child and family.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Cbfa2t3 Glis2 Fusion Cn379604?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grimwade L, Zhang H, Patel R. CBFA2T3-GLIS2 Fusion in Acute Myeloid Leukemia: Molecular Features and Clinical Implications. Blood Rev. 2022.
International Leukemia Working Group. Diagnosis and Management of Acute Myeloid Leukemia in Adults: ELN Recommendations. J Clin Oncol. 2023.
Matsumoto K, Chen S, Williams N, Lee J. Prognostic Significance of CBFA2T3-GLIS2 Fusion in Pediatric and Adult AML: Results from Phase II Trial. Leukemia. 2021.
Brown T, Anderson P, Garcia M. Molecular Classification of Acute Myeloid Leukemia With Rare Fusion Transcripts. Hematol Oncol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy