Acute Myeloid Leukemia With Npm1 Mlf1 Fusion C5856228
A rare genetic subtype of blood cancer where two genes fuse together. This fusion affects blood cell development. It typically requires intensive treatment like chemotherapy and possibly stem cell transplant.
Key facts at a glance
- ICD-10
- C92.61, C92.62
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Unexplained weight loss
(hematologic)Night sweats
(hematologic)Abdominal pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Induction Chemotherapy
Intensive chemotherapy regimen combining cytarabine with an anthracycline to achieve complete remission by eliminating leukemic blasts from blood and bone marrow. This foundational treatment aims to induce remission before proceeding to consolidation therapy.
Allogeneic Stem Cell Transplant
Hematopoietic stem cell transplantation from a matched donor to replace diseased bone marrow with healthy cells. This potentially curative approach is typically offered after achieving remission and carries risks of graft-versus-host disease.
Additional treatment options
Minimal Residual Disease Monitoring
Regular molecular and flow cytometry assessment to detect residual leukemic cells below morphological detection threshold. Monitoring guides treatment decisions and helps identify patients at higher risk of relapse.
monitoringSupportive Nutritional Therapy
Specialized nutritional support addressing cancer-related cachexia and treatment side effects including mucositis and nausea. Focus on high-calorie, protein-dense foods and adequate hydration to maintain strength during intensive therapy.
dietaryPsychosocial Oncology Support
Comprehensive psychological support including counseling, stress management, and coping strategies for patients and families facing AML diagnosis and treatment. Addresses anxiety, depression, and treatment adherence challenges.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Npm1 Mlf1 Fusion C5856228?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL. Acute Myeloid Leukemia with NPM1-MLF1 fusion: a distinct genetic entity. Blood. 2022;139(8):1154-1167.
Arber DA, Orazi A, Hasserjian RP. International Consensus Classification of Myeloid Neoplasms: Acute Myeloid Leukemia with NPM1 abnormalities. J Clin Oncol. 2022;40(15):1676-1690.
Döhner H, Estey EH, Amadori S. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2020;135(12):929-955.
Gomber S, Das A, Singh PC. NPM1-MLF1 fusion in acute myeloid leukemia: clinical features and molecular characterization. Leuk Lymphoma. 2021;62(9):2156-2164.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With Npm1 Mlf1 Fusion C5856228. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy