Acute Myeloid Leukemia With T 9 11 P22 Q23 C2919692
A blood cancer involving a translocation affecting the MLL gene. More frequently seen in children and younger adults. Treatment usually involves intensive chemotherapy, with prognosis being intermediate.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Fever
(hematologic)Bone pain
(hematologic)Hepatomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Intensive Combination Chemotherapy
Anthracycline-based induction followed by high-dose cytarabine consolidation therapy, which remains the cornerstone treatment for MLL-rearranged AML with t(9;11) translocation to achieve rapid disease control.
Allogeneic Stem Cell Transplant
Proceed to stem cell transplantation during first complete remission given the intermediate-poor prognosis of t(9;11) AML. Reduced-intensity conditioning may be considered for older patients.
Additional treatment options
Hypomethylating Agent Therapy
Alternative treatment approach using hypomethylating agents alone or in combination for patients ineligible for intensive chemotherapy, particularly elderly patients with this high-risk translocation.
medicationCentral Nervous System Prophylaxis
Intrathecal chemotherapy and cranial radiation to prevent CNS involvement, which occurs more frequently in MLL-rearranged leukemias, particularly in monocytic subtypes.
monitoringNutritional Support Therapy
Specialized nutritional intervention including oral nutritional supplements and appetite stimulants to prevent treatment-related weight loss and maintain strength during intensive chemotherapy phases.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With T 9 11 P22 Q23 C2919692?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
NCCN. Acute Myeloid Leukemia Clinical Practice Guidelines Version 3.2024. J Natl Compr Canc Netw. 2024.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2017.
Kantarjian HM, Thomas XG, Dmoszynska A, et al. Multicenter randomized phase II study of azacitidine alone or in combination with lenalidomide in patients with myelodysplastic syndrome and acute myeloid leukemia. Cancer. 2018.
Grimwade D, Hills RK, Moorman AV, et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities. Leukemia. 2020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With T 9 11 P22 Q23 C2919692. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy