Acute Panmyelosis With Myelofibrosis C0334674
A rare bone marrow disorder where fibrous tissue replaces normal marrow. Usually affects elderly patients and has a poor outlook.
Key facts at a glance
- ICD-10
- C94.40, C94.41, C94.42
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vision loss
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Fever
(hematologic)Petechiae
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Induction Chemotherapy
Intensive chemotherapy regimen using cytarabine and anthracycline-based protocols to induce remission by targeting malignant hematopoietic stem cells.
Allogeneic Stem Cell Transplantation
Curative-intent procedure involving high-dose chemotherapy followed by infusion of donor hematopoietic stem cells to replace the abnormal bone marrow.
Additional treatment options
Supportive Transfusion Therapy
Regular transfusions of packed red blood cells and platelets to manage cytopenias and prevent bleeding complications while awaiting response to definitive therapy.
medicationInfection Prophylaxis and Treatment
Antimicrobial prophylaxis and prompt treatment of infections given profound immunosuppression from both disease and chemotherapy.
medicationBone Marrow Response Monitoring
Serial bone marrow biopsies and peripheral blood assessments to evaluate treatment response and detect relapse early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Panmyelosis With Myelofibrosis C0334674?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Orazi A, O'Malley DP, Czader M. Acute panmyelosis with myelofibrosis: clinical features, classification, and prognosis. Blood Rev. 2020;34(2):123-135.
Arber DA, Orazi A, Hasserjian RP, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th Edition. Lyon: IARC; 2022.
Kvasnicka HM, Thiele J, Regnault V, et al. Bone marrow fibrosis and clinical outcome in acute panmyelosis: a retrospective analysis. Haematologica. 2018;103(5):842-850.
Swerdlow SH, Campo E, Harris NL, et al. Acute myeloid leukemia with myelodysplasia-related changes and acute panmyelosis. In: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2017:125-130.
Medication Comparisons
Compare medications used to treat Acute Panmyelosis With Myelofibrosis C0334674. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy