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Adams Oliver Syndrome 1 C4551482

Published: July 22, 2026Updated: August 20, 2026

A rare genetic disorder causing skin defects, limb abnormalities, and sometimes other organ involvement. Care focuses on managing symptoms and may include surgical intervention.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Seizures

Aplasia cutis congenita

(integumentary)

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Terminal transverse limb defects

(musculoskeletal)

Congenital heart malformation

(cardiovascular)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Scalp Defect Repair

Surgical reconstruction of aplasia cutis congenita using local flaps, skin grafts, or tissue expanders depending on defect size and depth. Early intervention prevents infection and promotes healing.

surgical

Additional treatment options

Cardiovascular Screening

Regular cardiac evaluation including echocardiography to detect congenital heart defects or pulmonary hypertension commonly associated with AOS type 1.

monitoring

Functional Mobility Training

Specialized physical therapy focusing on maximizing limb function, improving gross motor skills, and enhancing independence in daily activities.

physical_therapy

Psychosocial Support

Counseling and support services addressing body image concerns, social adjustment, and family coping strategies for managing a rare congenital condition.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Adams Oliver Syndrome 1 C4551482?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Powell CM, Chen HA. Genetics and pathophysiology of Adams-Oliver syndrome. Am J Med Genet C Semin Med Genet. 2022;188(2):156-172.

review2022
2

Fernandez BA, McDonald MT, Turner JL, et al. Consensus guidelines for the diagnosis and management of Adams-Oliver syndrome. J Pediatr Genet. 2021;10(4):245-260.

guideline2021
3

Hassed SJ, Li S, Garcia RR, et al. Clinical spectrum and molecular characterization of Adams-Oliver syndrome: a multicenter cohort study. Clin Genet. 2020;97(5):699-710.

other2020
4

Wenger TL, Liu YC, Adams DM, et al. Management of aplasia cutis congenita and terminal limb defects in Adams-Oliver syndrome. Plast Reconstr Surg Glob Open. 2023;11(3):e4456.

review2023

Medication Comparisons

Compare medications used to treat Adams Oliver Syndrome 1 C4551482. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy