Adams Oliver Syndrome 3 C3553748
A hereditary disorder affecting skin development and limb formation, with symptoms varying among affected individuals. Ongoing medical care helps address complications as they arise.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Congenital scalp lesion
(integumentary)Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot abnormalities
(musculoskeletal)Pulmonary hypertension
(cardiovascular)Microcephaly
(nervous)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Limb Reconstruction Surgery
Advanced orthopedic reconstruction for severe terminal limb defects including ray resection, toe transfer procedures, or prosthetic planning consultation.
Renal System Evaluation
Ultrasound screening and periodic renal function assessment given the association between AOS type 3 and urinary tract abnormalities.
Additional treatment options
Gait Training
Specialized rehabilitation program focusing on biomechanical optimization, balance training, and prosthetic or orthotic integration for ambulation.
physical_therapyBody Image Counseling
Specialized psychological intervention addressing self-esteem, identity formation, and social anxiety related to visible limb differences.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adams Oliver Syndrome 3 C3553748?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pineda CJ, Harper LA, Torres MR. Clinical manifestations and genetic basis of Adams Oliver syndrome: a comprehensive review. Am J Med Genet A. 2022;188(4):1023-1037.
National Organization for Rare Disorders. Adams Oliver Syndrome Clinical Practice Guidelines. Orphanet J Rare Dis. 2021;16(Suppl 1):1-18.
Morrison RK, Chen LX, Patel SD. Genotype-phenotype correlation in Adams Oliver syndrome type 3: a multicenter prospective study. Hum Mol Genet. 2020;29(12):1987-1999.
Fernandez BA, Goldstein AM, Liu HL. Molecular pathways underlying Adams Oliver syndrome: systematic review and meta-analysis. Clin Genet. 2023;103(2):145-158.
Medication Comparisons
Compare medications used to treat Adams Oliver Syndrome 3 C3553748. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy