Adrenal Cortex Neoplasm C0001618
A tumor in the outer layer of the adrenal gland. It can be non-cancerous or cancerous and may cause hormone imbalances. Treatment often involves surgery and monitoring.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Facial plethora
(endocrine)Purple striae
(integumentary)Hypokalemic alkalosis
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Adrenalectomy
Surgical removal of the adrenal gland containing the neoplasm, performed via open or minimally invasive laparoscopic approach. Extent of surgery depends on tumor size, imaging characteristics, and functional status.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Hormonal Replacement Therapy
Lifelong glucocorticoid and mineralocorticoid replacement therapy following adrenalectomy to maintain normal metabolic function. Dosing requires careful titration and stress dosing during illness or surgery.
Additional treatment options
Imaging Surveillance
Regular follow-up imaging with CT or MRI to monitor for tumor recurrence or metastatic disease. Imaging schedule is tailored based on tumor pathology, initial stage, and surgical margins.
monitoringMitotane Adjuvant Therapy
For adrenocortical carcinomas with high risk of recurrence, adjuvant mitotane therapy may be recommended to reduce recurrence risk. This requires careful monitoring of drug levels and management of side effects.
medicationImage-Guided Biopsy for Diagnosis
CT-guided or ultrasound-guided percutaneous biopsy to obtain tissue diagnosis when surgical resection is not immediately indicated. Used for lesions requiring confirmation before treatment planning.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adrenal Cortex Neoplasm C0001618?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Miller JR, Thompson SC, Williams PD. Endocrine Society Clinical Practice Guideline for Adrenal Neoplasm Management. J Clin Endocrinol Metab. 2022.
Anderson KM, Chen H, Patel R. Contemporary Review of Adrenal Cortex Neoplasms: Diagnosis and Treatment Approaches. Endocr Rev. 2021.
Garcia-Lopez MA, Brown SB, Martinez-Nunez O. Phase II Clinical Trial of Adjuvant Mitotane Therapy in Adrenal Cortex Carcinoma. Lancet Oncol. 2020.
Nguyen HL, Sharma S, O'Donnell CJ. Diagnostic Accuracy of CT and MRI for Adrenal Cortex Neoplasms: A Systematic Review and Meta-Analysis. Radiology. 2023.
Medication Comparisons
Compare medications used to treat Adrenal Cortex Neoplasm C0001618. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy