Adrenal Insufficiency C0001623
A condition where the adrenal glands do not produce enough essential hormones, affecting individuals of all ages. Lifelong hormone replacement therapy is the main treatment approach.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Glucocorticoid Replacement Therapy
Lifelong hormone replacement with synthetic glucocorticoids to replace deficient cortisol production. Dosing typically follows circadian rhythm with higher morning doses.
Mineralocorticoid Replacement
Fludrocortisone supplementation for primary adrenal insufficiency to restore sodium retention and potassium excretion. Blood pressure and electrolyte monitoring guide dosing.
Additional treatment options
Emergency Adrenal Crisis Kit
Carrying injectable hydrocortisone and detailed emergency instructions at all times. Training for self-administration during medical emergencies, trauma, or severe illness.
lifestyleIncreased Sodium Intake
Dietary sodium supplementation particularly important in primary adrenal insufficiency. Regular meal timing helps maintain stable blood glucose and energy levels.
dietaryRegular Hormone Level Testing
Periodic assessment of cortisol, ACTH, and electrolyte levels to optimize replacement therapy dosing and detect complications early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adrenal Insufficiency C0001623?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364-389.
Husebye ES, Pearce SH, Krone NP, Kämpe O. Adrenal Insufficiency. Lancet. 2021;397(10274):613-629.
Ng SM, Agwu JC, Dwan K. Hydrocortisone Versus Prednisolone for Congenital Adrenal Hyperplasia: A Randomized Controlled Trial. J Pediatr Endocrinol Metab. 2020;33(4):461-469.
Quinkler M, Ekman B, Zhang P, Isidori AM, Murray RD. Meta-Analysis of Hydrocortisone Replacement Regimens in Adrenal Insufficiency. Eur J Endocrinol. 2022;186(3):283-294.
Medication Comparisons
Compare medications used to treat Adrenal Insufficiency C0001623. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy