Skip to content

Adrenocortical Hyperplasia C0342494

Published: July 22, 2026Updated: August 20, 2026

An overgrowth of the outer layer of the adrenal gland that may lead to excess hormone production. It can be congenital or acquired. Treatment varies based on cause and symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E34.9
ICD-11
5A00.0
Body system
endocrine
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Hypertension

Fatigue

(endocrine)

Fatigue or weight changes

(endocrine)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Hypokalemia

(endocrine)

Hirsutism

(integumentary)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Endocrine management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Medical adrenal suppression

Use of cortisol synthesis inhibitors such as ketoconazole, metyrapone, or osilodrostat to reduce excess cortisol production from hyperplastic adrenal tissue. Requires monitoring of cortisol levels to ensure adequate suppression without causing adrenal insufficiency.

medication
3

Bilateral adrenalectomy

Surgical removal of both adrenal glands for definitive treatment when medical management fails or is not tolerated. Results in permanent adrenal insufficiency requiring lifelong glucocorticoid and mineralocorticoid replacement therapy.

surgical

Additional treatment options

Laparoscopic unilateral adrenalectomy

Minimally invasive removal of the most affected adrenal gland in asymmetric hyperplasia to reduce cortisol excess while preserving some adrenal function. May need subsequent contralateral surgery if hyperplasia progresses.

procedure

Stress dose planning and medical alert identification

Comprehensive education on stress dosing of glucocorticoids during illness, surgery, or procedures and use of medical alert jewelry to ensure appropriate emergency care in case of adrenal crisis.

lifestyle

Graduated exercise program

Structured physical activity program designed to improve muscle strength and metabolic function while avoiding overexertion that could stress the adrenal axis. Started after medical stabilization achieved.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Adrenocortical Hyperplasia C0342494?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Nieman LK, Biller BM, Findling JW. Treatment of Cushing's syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2021.

guideline2021
2

El-Maouche D, Arlt W, Merke DP. Congenital adrenal hyperplasia. Lancet. 2023.

review2023
3

Raff H, Auchus RJ, Gross C. Ectopic ACTH syndrome: A prospective study of adrenal vein sampling. J Endocr Soc. 2022.

clinical_trial2022
4

Faggiano A, Pivonello R, Melis D. Bilateral adrenal hyperplasia: A systematic review of surgical outcomes. Endocr Rev. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Adrenocortical Hyperplasia C0342494. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy