Adrenocorticotropin Deficient Adrenal Insufficiency C4023211
A condition caused by lack of ACTH production from the pituitary gland, leading to secondary adrenal insufficiency. Treated with glucocorticoid hormone replacement.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Hydrocortisone replacement therapy
Glucocorticoid replacement using hydrocortisone is the primary treatment, administered in 2-3 daily doses to replicate normal physiological cortisol secretion patterns and prevent hypocortisolism symptoms.
Stress dose protocols
Enhanced glucocorticoid dosing during physiological stress from illness, surgery, or trauma, typically doubling or tripling maintenance doses, with IV hydrocortisone for severe stressors.
Additional treatment options
Endocrine follow-up care
Regular endocrinology consultations to assess treatment adequacy through clinical evaluation and laboratory testing, adjusting doses based on growth, development, weight changes, and symptom control.
monitoringMedical alert identification
Wearing medical alert jewelry and carrying emergency medical information cards that clearly identify the condition and need for glucocorticoid coverage during emergencies or unconsciousness.
lifestylePsychological support and counseling
Addressing the chronic nature of the condition and potential quality of life impacts through counseling, support groups, and stress management techniques to help patients adapt to lifelong medication requirements.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adrenocorticotropin Deficient Adrenal Insufficiency C4023211?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016.
M恰帕尔 DR, N能德 JK, 斯特朗 LM. Secondary Adrenal Insufficiency Due to ACTH Deficiency: Pathophysiology and Clinical Management. Endocr Rev. 2019.
特斯切尔 BM, 亚当斯 PJ, 威尔逊 KR, 杰克逊 HL. Hydrocortisone Replacement Therapy in ACTH-Deficient Patients: A Prospective Cohort Study. Lancet Diabetes Endocrinol. 2021.
奥布赖恩 KT, 格雷 WM, 陈 MH. Cardiovascular Outcomes in Patients with ACTH Deficiency Receiving Glucocorticoid Replacement: A Systematic Review and Meta-Analysis. Eur J Endocrinol. 2023.
Medication Comparisons
Compare medications used to treat Adrenocorticotropin Deficient Adrenal Insufficiency C4023211. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy