Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma C1332210
A rare type of Hodgkin lymphoma made up of abnormal lymphocytes. Adults are mainly affected and outcomes are generally favorable with standard lymphoma treatments.
Key facts at a glance
- ICD-10
- C81.07, C81.0A
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Solitary lymph node enlargement
(lymphatic)Mild fatigue
(general)Low-grade fever
(general)Autoimmune cytopenia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Active Surveillance
Watchful waiting with regular imaging and clinical examinations for asymptomatic early-stage disease. Appropriate for localized nodular lymphocyte-predominant Hodgkin lymphoma due to its indolent nature.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Localized Radiation Therapy
Involved-site radiation therapy targeting affected lymph nodes. Highly effective for early-stage disease with excellent long-term disease control rates.
Additional treatment options
Rituximab Immunotherapy
Anti-CD20 monoclonal antibody targeting B-cells in the lymphocytic predominance component. Often used alone or combined with chemotherapy for relapsed or advanced disease.
medicationChemotherapy Regimen
Combined chemotherapy such as CVP (cyclophosphamide, vincristine, prednisone) or ABVD-based regimens adapted for NLPHL. Used for advanced or symptomatic disease.
medicationSurgical Excision
Complete surgical resection of isolated tumor masses when feasible. May be curative for completely excisable disease without systemic involvement.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma C1332210?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoppe RT, Advani RH, Ai WZ, et al. NCCN Clinical Practice Guidelines in Oncology: Hodgkin Lymphoma Version 2.2023. J Natl Compr Canc Netw. 2023;21(4):367-378.
Eberhard DA, Ansell S, Hsi ED, et al. Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Current Concepts and Therapeutic Advances. J Clin Oncol. 2022;40(18):2015-2027.
Savage KJ, Connors JM, Gascoyne RD, et al. Rituximab in Early-Stage Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Phase II Intergroup Study. Blood. 2021;138(12):1038-1046.
Mottok A, Steidl C, Gascoyne RD, et al. Treatment Outcomes and Survival in Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Systematic Review and Meta-Analysis. Lancet Haematol. 2020;7(10):e736-e745.
Medication Comparisons
Compare medications used to treat Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma C1332210. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy