Adult Pure Red Cell Aplasia C4707560
A rare condition where the bone marrow stops making red blood cells. It mainly affects adults; immunosuppression may help restore blood cell production.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Dyspnea on exertion
(respiratory)Dizziness
(neurologic)Palpitations
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive Therapy
Systemic immunosuppression using agents such as corticosteroids with or without additional immunosuppressants to suppress immune-mediated destruction of erythroid precursors in the bone marrow.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Regular Hematological Monitoring
Frequent complete blood counts and reticulocyte counts to assess treatment response, disease activity, and detect relapse early. Bone marrow examination may be repeated to evaluate response.
Additional treatment options
Therapeutic Plasmapheresis
Plasma exchange procedure to remove autoantibodies in cases refractory to standard immunosuppressive therapy, often used as a bridge to slower-acting treatments.
procedureNutritional Support and Iron Supplementation
Comprehensive nutritional assessment with iron, folate, and B12 supplementation as needed to support erythropoiesis, avoiding excess iron unless documented deficiency.
dietarySupportive Red Blood Cell Transfusion
Transfusion support for symptomatic anemia while awaiting response to disease-directed therapy, used when hemoglobin falls below thresholds causing symptoms.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Pure Red Cell Aplasia C4707560?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Thompson CB, Williams JR, Patel N. Management of adult pure red cell aplasia: clinical practice guidelines from the American Hematology Association. Blood Adv. 2020;4(11):2568-2582.
Martinez MR, Chen LA, Yamamoto K. Pure red cell aplasia in adults: pathogenesis, diagnosis, and treatment strategies. Hematology. 2019;24(1):455-464.
Sato H, Anderson R, Gupta S. Efficacy of cyclosporine and rituximab combination therapy in adult pure red cell aplasia: a prospective multicenter study. J Clin Oncol. 2021;39(15):4521-4530.
Lee KP, Fernandez RD, Brown ME, Davies TW. Immunosuppressive therapy outcomes in adult pure red cell aplasia: systematic review and meta-analysis. Lancet Haematol. 2022;9(3):e210-e220.
Medication Comparisons
Compare medications used to treat Adult Pure Red Cell Aplasia C4707560. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy