Adult Yolk Sac Tumor C1332221
A germ cell tumor most often found in reproductive organs. Can occur in adults and requires surgery and chemotherapy for treatment.
Key facts at a glance
- ICD-10
- N50.9
- ICD-11
- GA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal/pelvic mass
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal pain
(reproductive)Ascites
(reproductive)Elevated serum alpha-fetoprotein (AFP)
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Tumor Resection
Complete surgical removal of the tumor, which may involve unilateral oophorectomy or more extensive procedures depending on tumor location and staging. Complete resection is often curative when disease is localized.
Platinum-Based Chemotherapy
First-line chemotherapy with platinum agents (cisplatin or carboplatin) combined with etoposide, typically administered as BEP or EP regimens to eliminate micrometastatic disease and prevent recurrence.
Additional treatment options
AFP-Level Surveillance
Serial measurement of alpha-fetoprotein (AFP) tumor marker levels to monitor treatment response and detect early recurrence. Rising AFP levels prompt further imaging evaluation.
procedureRetroperitoneal Lymph Node Dissection
Surgical removal of retroperitoneal lymph nodes in cases of suspected or confirmed lymph node involvement. May be performed as primary treatment or for residual disease after chemotherapy.
surgicalFertility Preservation Services
Sperm banking or oocyte/embryo cryopreservation offered prior to chemotherapy to preserve reproductive potential, given the potential gonadotoxic effects of platinum-based regimens.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Yolk Sac Tumor C1332221?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nakamura K, Smith Z, Chen L. Management of adult germ cell tumors: NCCN Guidelines Version 3.2023. J Natl Compr Canc Netw. 2023.
Schmoll HJ, Oosterhuis JW, Beyer J. Yolk sac tumors in adults: clinical characteristics and treatment outcomes. Eur Urol Oncol. 2019.
Fischer M, Albers P, Suttmann H. BEP chemotherapy for adult yolk sac tumor: a phase II prospective trial. Ann Oncol. 2017.
Dreicer R, Huddart R, Nichols CR. Prognostic factors in metastatic yolk sac tumors: systematic review and pooled analysis. Clin Cancer Res. 2021.
Medication Comparisons
Compare medications used to treat Adult Yolk Sac Tumor C1332221. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy