Alk Negative Anaplastic Large Cell Lymphoma C1332078
A rare and aggressive type of non-Hodgkin lymphoma that lacks the ALK gene rearrangement. It can affect both children and adults, often involving lymph nodes and skin. Treatment typically involves chemotherapy and may require more intensive approaches than ALK-positive cases.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Painless lymphadenopathy
(hematologic)Fever
(hematologic)Night sweats
(hematologic)Pruritic skin lesions
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Multiagent Chemotherapy Regimen
Standard chemotherapy protocols for ALK-negative ALCL typically involving cyclophosphamide, doxorubicin, vincristine, and prednisone-based regimens. Treatment intensity based on disease stage and patient performance status with careful toxicity management.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Central Venous Access Placement
Implantation of central venous catheters for chemotherapy administration, blood products, and frequent blood draws. Includes tunneled catheters or ports based on treatment duration and patient preference.
Additional treatment options
Excisional Lymph Node Biopsy
Surgical biopsy for definitive diagnostic confirmation and adequate tissue for pathological assessment including immunohistochemistry and molecular studies essential for ALK-negative ALCL diagnosis.
surgicalResponse Assessment and Surveillance
Regular imaging studies including PET-CT scans for treatment response evaluation and detection of relapse. Includes interim imaging during treatment and post-treatment surveillance protocols.
monitoringSupportive Care Integration
Integrative supportive therapies including nutritional counseling, pain management, nausea control, and psychological support. Addresses quality of life during intensive treatment with complementary approaches.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alk Negative Anaplastic Large Cell Lymphoma C1332078?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Guidelines Version 2.2023: Peripheral T-Cell Lymphomas. J Natl Compr Canc Netw. 2023.
Savage KJ, Ferreri AJ, Zinzani PL. Peripheral T-Cell Lymphomas: Dissecting the Biological and Clinical Heterogeneity of a Rare Disease Entity. Blood. 2021.
Horwitz SM, Advani RH, Bartlett NL, et al. Brentuximab Vedotin in Patients with Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma. J Clin Oncol. 2019.
Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy