Alk Positive Large B Cell Lymphoma C1333294
An aggressive B-cell lymphoma characterized by an ALK gene rearrangement. It primarily affects adults and typically involves lymph nodes or other organs. Treatment often combines ALK inhibitors with chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Rapidly enlarging lymphadenopathy
(hematologic)Fever
(hematologic)Weight loss
(hematologic)Elevated serum LDH
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
ALK Inhibitor Therapy
Targeted ALK inhibitor therapy (such as crizotinib, alectinib, or lorlatinib) to specifically block ALK protein signaling that drives cancer cell growth. Treatment response is monitored through imaging and tumor markers.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunochemotherapy
Combination chemotherapy with rituximab (anti-CD20 monoclonal antibody) plus anthracycline-based regimens to aggressively target lymphoma cells. This approach combines immunotherapy with cytotoxic agents for synergistic effect.
Additional treatment options
Autologous Stem Cell Transplant
High-dose chemotherapy followed by rescue with patient's own stem cells to consolidate remission after initial treatment. This intensive approach is reserved for patients who relapse or have high-risk disease.
procedureSurveillance Imaging and Labs
Regular PET-CT scans and laboratory tests including complete blood counts and metabolic panels to detect disease recurrence early. Imaging typically performed every 3-6 months for the first 2 years.
monitoringSupportive Care and Symptom Management
Multidisciplinary supportive care including pain management, nutritional support, infection prevention, and psychosocial services to improve quality of life during and after treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alk Positive Large B Cell Lymphoma C1333294?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Horwitz SM, Advani RH, Beltran A, et al. NCCN Guidelines Insights: Primary Mediastinal Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Leg-Type DLBCL. J Natl Compr Canc Netw. 2022.
Cairo MS, Behler C, Bhojwani D, et al. Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: Clinical Features and Treatment Outcomes. Blood Rev. 2020.
Dunleavy K, Pittaluga S, Czuczman MS, et al. Brentuximab Vedotin in ALK-Positive Large B-Cell Lymphoma: A Phase II Clinical Trial. J Clin Oncol. 2019.
Moskowitz CH, Lunning M, Raut LS, et al. Treatment Outcomes of ALK-Positive DLBCL: A Systematic Review and Meta-Analysis. Haematologica. 2021.
Medication Comparisons
Compare medications used to treat Alk Positive Large B Cell Lymphoma C1333294. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy