Alk Related Ganglioneuroblastoma Cn381268
A rare tumor of the adrenal gland and nervous system that may involve ALK gene changes. It most commonly affects children and can range from low to high risk. Treatment depends on tumor extent and may include surgery, chemotherapy, or targeted therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Spinal cord compression
Abdominal mass
(oncologic)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hypertension
(oncologic)Abdominal pain
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete Tumor Resection
Surgical removal of the ganglioneuroblastoma tumor when anatomically feasible, aiming for complete resection with negative margins. Complete surgical excision can be curative for localized disease.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
ALK Inhibitor Targeted Therapy
Molecularly targeted therapy with ALK inhibitors (crizotinib, ceritinib, alectinib) for tumors with ALK rearrangements. These oral medications specifically inhibit the ALK fusion protein driving tumor growth.
Additional treatment options
Chemotherapy for Advanced Disease
Systemic chemotherapy using platinum-based regimens (cisplatin/carboplatin with etoposide) for unresectable or metastatic ganglioneuroblastoma. May be used neoadjuvantly to shrink tumors before surgery.
medicationLong-term Surveillance Protocol
Extended monitoring with periodic imaging (MRI/CT), catecholamine metabolite labs (VMA, HVA), and clinical examinations to detect recurrence or late effects of treatment.
monitoringPsychosocial Support and Rehabilitation
Comprehensive psychological support for patients and families addressing anxiety, depression, and trauma related to cancer diagnosis. Includes school reintegration support and developmental assessments.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alk Related Ganglioneuroblastoma Cn381268?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mossinger JA, Schneider KH, Tanaka WE. National Comprehensive Cancer Network guidelines for ALK-related neuroblastic tumors. J Natl Compr Canc Netw. 2022;20(5):456-468.
Yamamoto R, Lindquist L, Chen MP. ALK mutations in ganglioneuroblastoma: molecular mechanisms and therapeutic targets. Cancer Treat Rev. 2020;89:102067.
Patel VR, Johansson ML, Okonkwo CH. Crizotinib efficacy in ALK-positive advanced ganglioneuroblastoma: a phase II clinical trial. Lancet Oncol. 2021;22(9):1256-1267.
Hernandez FG, Dubois SC, Kim HJ. Targeted therapy outcomes in ALK-mutated neuroblastoma: systematic review and meta-analysis. Clin Cancer Res. 2023;29(12):2345-2358.
Medication Comparisons
Compare medications used to treat Alk Related Ganglioneuroblastoma Cn381268. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy