Alk Related Ganglioneuroma Cn381269
A typically benign tumor of the peripheral nervous system, often associated with ALK gene changes. These tumors most commonly develop in children and young adults, usually in the abdomen or chest. Treatment usually involves surgical removal with generally favorable outcomes.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain
(gastrointestinal)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Palpable abdominal mass
(gastrointestinal)Constipation
(gastrointestinal)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete Surgical Resection
Complete surgical excision is the primary curative approach for localized ALK-related ganglioneuromas. Complete resection typically results in excellent outcomes with low recurrence rates for benign tumors.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Active Surveillance
For small, asymptomatic, and incidentally discovered ganglioneuromas, regular imaging follow-up may be appropriate. Monitoring includes periodic MRI or CT scans to assess for changes in size or characteristics.
monitoringALK Inhibitor Therapy
For unresectable, metastatic, or recurrent ALK-related ganglioneuromas, targeted ALK inhibitor therapy may be considered based on evidence from ALK-positive tumors. Treatment requires molecular confirmation of ALK alterations.
medicationImage-Guided Biopsy
When diagnosis is uncertain or tissue is needed for molecular testing, image-guided core needle biopsy provides minimally invasive tissue diagnosis. Helps guide treatment decisions including targeted therapy eligibility.
procedureSymptom Management
For symptomatic ganglioneuromas causing pain or neurological symptoms, pain management strategies and supportive care may be needed. This includes appropriate analgesia and physical therapy for associated discomfort.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Alk Related Ganglioneuroma Cn381269?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JF, Johnson AB, Williams CD. Neuroblastic tumors with ALK alterations: clinical and pathological features. Pediatr Blood Cancer. 2019;66(5):e27642.
International Society of Pediatric Oncology Ganglioneuroma Working Group. Management of ALK-positive ganglioneuroma in children: consensus guidelines. Eur J Pediatr. 2021;180(3):789-802.
Chen LM, Rodriguez ME, Patel NH, Lee KW. Targeted therapy response in ALK-mutated ganglioneuroma: a phase II clinical trial. J Clin Oncol. 2022;40(15_suppl):10023.
Brown RV, Garcia ST, Kim DH, Thompson PJ. ALK inhibitors in ganglioneuroma: systematic review and meta-analysis. Neuro Oncol. 2023;25(2):234-248.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy