Allan Herndon Dudley Syndrome C0795889
A genetic disorder affecting thyroid hormone transport, causing intellectual disability and movement problems. Treatment focuses on managing thyroid function and supportive therapies.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intellectual disability
(neurologic)Developmental delay
(neurologic)Hypotonia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Liothyronine (T3) Hormone Replacement
Liothyronine (T3) replacement is the cornerstone of management as patients cannot properly convert T4 to active T3. This helps restore metabolic function and supports neurodevelopment.
Regular Thyroid Function Monitoring
Frequent measurement of free T4, free T3, and TSH levels to optimize hormone replacement dosing and detect treatment responses or complications early.
Additional treatment options
Developmental Physical Therapy
Early intervention physical therapy focusing on motor development, muscle tone management, and prevention of contractures to maximize functional mobility and independence.
physical_therapyNeurodevelopmental Support Services
Comprehensive neurodevelopmental assessment and educational support services to address intellectual disability and provide appropriate learning accommodations throughout life.
psychologicalNutritional Support and Optimization
Balanced nutrition with adequate calories and protein to support growth and development, particularly important in children with increased metabolic demands from thyroid dysfunction.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Allan Herndon Dudley Syndrome C0795889?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Allan Herndon Dudley Syndrome C0795889. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy