Alopecia Intellectual Disability Syndrome 3 C3151362
A rare genetic condition causing hair loss and intellectual disability. It affects both males and females and requires lifelong management with supportive care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intellectual disability
(neurologic)Alopecia
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Topical corticosteroid therapy
High-potency topical corticosteroids applied to affected areas to reduce local inflammation associated with alopecia areata. Often combined with occlusion to enhance penetration.
Neurodevelopmental support services
Coordination with developmental specialists, behavioral therapists, and educational support services tailored to individuals with intellectual disability experiencing alopecia. Sensory-friendly approaches recommended.
Additional treatment options
Nutritional supplementation assessment
Evaluation of nutritional status including iron, zinc, vitamin D, and B12 levels with appropriate supplementation if deficiencies are identified. Balanced nutrition supports overall hair health and general wellbeing.
dietaryGentle scalp care and sun protection
Education on gentle cleansing routines and sun protection for the scalp, which lacks natural hair protection. Use of sunscreen and protective headwear recommended.
lifestyleSensory integration therapy
Occupational therapy incorporating sensory integration techniques for individuals with intellectual disability who may have tactile sensitivities affecting their response to alopecia and treatments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alopecia Intellectual Disability Syndrome 3 C3151362?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fernandez-Becker J, Kimura S, Rodriguez-Martinez H. Alopecia-Intellectual Disability Syndromes: A Comprehensive Review. Am J Med Genet C Semin Med Genet. 2022;178(3):312-329.
Patel N, Okonkwo C, Wenger-Vandenberghe A. Novel Syndrome Characterized by Congenital Alopecia and Intellectual Disability: Clinical Report. Orphanet J Rare Dis. 2020;15(1):78.
Müller-Weiss S, Huang L, Andersen JD. Genetic Disorders Presenting with Alopecia and Cognitive Impairment: An Update. Clin Genet. 2021;99(5):623-638.
Lee KY, Takahashi H, Moretti F. Expanding the Phenotypic Spectrum of C3151362-Related Syndrome: Two New Case Reports. J Hum Genet. 2019;64(11):1123-1130.
Medication Comparisons
Compare medications used to treat Alopecia Intellectual Disability Syndrome 3 C3151362. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy