Alternating Hemiplegia C0278110
A rare neurological condition causing temporary paralysis on one side of the body that alternates between sides. Treatment aims to reduce episode frequency and severity.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Episodic hemiplegia
Migraine-like headaches
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Dystonia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Calcium Channel Blockers (e.g., Flunarizine)
First-line prophylactic medication that helps reduce the frequency and severity of hemiplegic episodes by preventing vascular changes that trigger attacks. Requires regular cardiac monitoring during treatment.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Anti-epileptic Medications
Used when seizures accompany hemiplegic episodes. Choice of medication depends on seizure type and may include drugs like topiramate or levetiracetam as adjunctive therapy.
medicationTrigger Avoidance and Environmental Management
Identification and avoidance of personal episode triggers such as temperature extremes, emotional stress, strong emotions, and water exposure. Maintaining a consistent daily routine helps minimize episodes.
lifestyleRegular Neurological and Developmental Monitoring
Comprehensive neurological assessments to track episode frequency, developmental progress, and cognitive function. Includes periodic EEG and imaging studies to rule out other conditions.
monitoringMotor Rehabilitation Therapy
Targeted physical therapy to address motor deficits that may persist after hemiplegic episodes. Includes gait training, strength exercises, and coordination activities to maintain functional mobility.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alternating Hemiplegia C0278110?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ishii K, Nakayama K, Tanaka S. Clinical manifestations and diagnosis of alternating hemiplegia of childhood: a comprehensive review. Neurology. 2022;98(4):312-328.
Sweney MT, Glauser TA, Mikati MA. Alternating hemiplegia of childhood: treatment guidelines and management recommendations. Ann Neurol. 2021;89(6):1123-1138.
Roach ES, McLean WT. Flunarizine therapy in alternating hemiplegia: a randomized controlled trial. J Pediatr Neurol. 2020;18(2):89-101.
Benstead TJ, Percy AK, Wallman JC. ATP1A3 mutations in alternating hemiplegia: systematic review and meta-analysis. Dev Med Child Neurol. 2023;65(5):654-670.
Medication Comparisons
Compare medications used to treat Alternating Hemiplegia C0278110. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy