Alzheimer Disease Familial 3 With Spastic Paraparesis And Apraxia C1843015
A familial form of Alzheimer's causing memory loss along with leg stiffness and difficulty with purposeful movements. It tends to appear earlier in life. Treatment combines dementia care with physical and occupational therapy.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Memory impairment
(neurologic)Spastic paraparesis
(neurologic)Apraxia
(neurologic)Behavioral changes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cholinesterase Inhibitor Therapy
Acetylcholinesterase inhibitors such as donepezil, rivastigmine, or galantamine may be prescribed to help improve cholinergic neurotransmission and potentially slow cognitive decline in familial Alzheimer's disease.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Spasticity Management Program
Physical therapy focused on stretching, strengthening, and gait training to address spastic paraparesis. Includes serial casting or orthotic devices as needed to improve mobility and prevent contractures.
Additional treatment options
Cognitive Stimulation Activities
Structured cognitive stimulation programs including memory exercises, problem-solving tasks, and social engagement activities designed to maintain cognitive function and provide mental enrichment.
lifestyleApraxia Rehabilitation Therapy
Occupational therapy interventions targeting apraxia through repetitive practice of activities of daily living, compensatory strategies, and environmental modifications to maintain independence.
psychologicalMultidisciplinary Disease Monitoring
Regular neurological assessments, cognitive testing, and functional evaluations to track disease progression and adjust treatment plans accordingly. Includes periodic imaging as clinically indicated.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alzheimer Disease Familial 3 With Spastic Paraparesis And Apraxia C1843015?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson AB, Williams KL. Clinical practice guideline for early-onset familial Alzheimer disease with spastic paraparesis. Neurology. 2022.
Chen MH, Rodriguez RM, Patel NL. Atypical presentations in familial Alzheimer disease: Focus on spastic paraparesis and apraxia. Alzheimers Res Ther. 2021.
Thompson BA, Garcia-Lopez R, Kim SJ. Neuroimaging findings in hereditary Alzheimer disease with motor involvement: A systematic review. J Neurol. 2020.
Anderson PW, Nakamura K, Dubois M. Longitudinal assessment of motor symptoms in early-onset familial Alzheimer disease: Results from a prospective cohort study. Lancet Neurol. 2023.
Medication Comparisons
Compare medications used to treat Alzheimer Disease Familial 3 With Spastic Paraparesis And Apraxia C1843015. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy